It has been nearly two years since the COVID-19 epidemic hit the world, with more than 200 million confirmed cases and more than 4 million deaths worldwide. The epidemic has also disrupted the world's industrial chain and economic, political, and social order, resulting in a significant contraction of the global economy and trade. The cumulative economic damage is no less than tens of trillions of dollars. As a result of the COVID-19 epidemic, many important changes have occurred in world politics, some of which are of historical significance, including: the trend of international power contrast has accelerated significantly, with the East rising and the West falling, and China rising and the U.S. falling; the international pattern and international order dominated by the U.S. and other Western countries since the end of the Cold War has accelerated its adjustment, and the influence of non-Western countries, mainly emerging countries such as China and Russia, has risen significantly; the economic, political, cultural and racial superiority that western countries have long harbored has been weakened due to the failure to fight the disease, and new changes in the dynamics of the two systems have emerged; it is more difficult for the U.S. and the West to push their democracy and market system globally, thus the world's political and economic development models will become more diversified; non-western countries will have expanded opportunities to choose their economic and political development models, according to their own people's conditions, national circumstances, and historical development stages, thus the world's economic, political, and cultural development will become more multi-polarized and diversified; due to the COVID-19 epidemic, the pace of China's total economic volume catching up with that of the United States will be significantly accelerated, and the timetable of "surpassing the United States" in total economic volume will also be accelerated. China-US relations will continue to operate within the framework of "competition, limited confrontation, and cooperation" and will have a broader impact on world politics.